# Complete the RhoGAM dose calculation for an Rh-negative postpartum client with a quantified exposure of 22 mL Rh-positive red blood cells.

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> url: https://mymerci.kr/pages/nclex_q.php?qn_id=514123&lang=en  
> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

Complete the RhoGAM dose calculation for an Rh-negative postpartum client with a quantified exposure of 22 mL Rh-positive red blood cells.

The calculated dose is ::선택::220 mcg300 mcg440 mcg660 mcg. The nurse should prepare ::선택::1 300-mcg syringe2 300-mcg syringes3 300-mcg syringes1 50-mcg syringe for a total authorized dose of ::선택::300 mcg440 mcg600 mcg900 mcg.

## Explanation

At 20 mcg per 1 mL, 22 mL requires 440 mcg. Because 1 syringe contains 300 mcg and the label directs rounding up to a whole syringe, prepare 2 syringes for an authorized total of 600 mcg within 72 hours.

## In-depth explanation

Quick answer
Calculate 440 mcg, then round up to 2 whole 300-mcg syringes.

Why this is correct
Use the labeled calculation: 22 mL times 20 mcg per 1 mL equals 440 mcg. 1 syringe is insufficient, so 440 divided by 300 is rounded up to 2 syringes.

Easy analogy or mental picture
If the calculated load exceeds 1 container, the remaining partial amount still requires 1 whole prepared syringe.

Memory hook
mL RBC times 20 mcg; divide by 300 and round up.

NCLEX decision rule
Use the measured Rh-positive red-cell volume, preserve units through the calculation, and round only at the final 1-syringe step.

Why the other choices are wrong
Rounding down leaves part of the exposure uncovered, and using fetal whole-blood volume instead of the reported red-cell volume changes the calculation.References
1DailyMed: RhoGAM Ultra-Filtered PLUSTwenty micrograms per mL of Rh-positive red cells and rounding up to whole syringes

## Clinical scenario

Rh immune globulin calculation
Confirm maternal and newborn Rh status, quantified red-cell exposure, mcg per 1 mL, syringe strength, rounding rule, route, and timing.

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