# A client is beginning long-term hydroxychloroquine therapy for systemic lupus erythematosus. Which instruction should the nurse include?

> source: MyMerci (mymerci.kr)  
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> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

A client is beginning long-term hydroxychloroquine therapy for systemic lupus erythematosus. Which instruction should the nurse include?

## Option

1. Skip eye testing unless visual symptoms interfere with reading or driving safely
2. Stop the medication without guidance when mild nausea occurs after a dose
3. Use nonprescription eye drops in place of scheduled retinal examinations
4. Attend recommended retinal screening and report new visual changes promptly **✔ Correct answer**

**Correct answer: 4**

## Explanation

Hydroxychloroquine retinal toxicity may progress before the client notices symptoms and can be irreversible. Recommended retinal screening supports early detection, while new visual changes require prompt assessment rather than self-discontinuation.

## In-depth explanation

Quick answer
Keep recommended retinal examinations and promptly report new visual changes during hydroxychloroquine therapy.

Why this is correct
Screening with appropriate retinal testing can detect toxicity before substantial functional loss. Risk depends on dose, duration, kidney function, and other factors, so the ophthalmic schedule is individualized and symptoms should trigger timely evaluation.

Easy analogy or mental picture
Retinal screening works like checking a smoke detector before smoke fills the room. It can reveal early risk, but the analogy does not mean every visual symptom represents hydroxychloroquine toxicity.

Memory hook
Hydroxychloroquine means retinal schedule plus rapid reporting of vision change.

NCLEX decision rule
For medications with potentially irreversible organ toxicity, teach planned surveillance and early symptom reporting. Do not recommend symptom-only monitoring, self-stopping, or comfort products as substitutes for objective screening.

Why the other choices are wrong
Waiting for impaired function can miss early toxicity. Nausea does not justify unsupervised withdrawal, and lubricating drops do not evaluate retinal injury.References

- [1]NCSBN: 2026 NCLEX-RN Test PlanNational Council of State Boards of Nursing

- [2]Special AAO Report: Hydroxychloroquine Retinopathy Screening, 2025 RevisionAmerican Academy of Ophthalmology; Ophthalmology, 2026

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