# A nurse is administering a unit of FFP to correct a coagulopathy. Which administration practice is correct?

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=391885&lang=en  
> language: en  
> subject: Medical Emergencies  
> category: PA

## Question

A nurse is administering a unit of FFP to correct a coagulopathy. Which administration practice is correct?

## Option

1. Infuse over 6 hours to minimize fluid overload, using a 170-micron filter and NS, with premedication of diphenhydramine; platelets require slower infusion due to risk of hypotension.
2. Keep the FFP refrigerated during the infusion using a cold pack, and infuse over 3 hours through a leukocyte removal filter to reduce allergic reactions.
3. Dilute with D5W to a total of 300 mL and infuse over 2 hours using a blood warmer; monitor for hyperglycemia, hypothermia, and citrate toxicity.
4. Infuse over 30 minutes (or up to 4 hours), use NS only, monitor for allergic and circulatory reactions; platelets are infused at similar pace via filtered tubing **✔ Correct answer**

**Correct answer: 4**

## Explanation

Correct (2): FFP contains all clotting factors; infuse over 30 minutes (max 4 hours). Use NS only via filtered tubing. Platelets infuse over 30-60 min; do NOT refrigerate (room temp), and gently agitate the bag. Watch for allergic reactions (more common with plasma/platelet than PRBC). (1) Too slow risks bacterial growth. (3) D5W hemolyzes. (4) Refrigeration ruins platelets.

## In-depth explanation

Memory Tip FFP = "Fresh Frozen Plasma → infuse fast, factors active 24h thawed". Platelets = "Room temp, no refrigerate". Cryoprecipitate = fibrinogen + factor VIII.

## Clinical scenario

Scenario Adult with coagulopathy (INR 3.5, active bleeding) receives FFP 1 unit. NS 0.9% available.

## Key concepts

- **FFP (fresh frozen plasma)** — All coagulation factors; for coagulopathy and rapid warfarin reversal.
- **Platelet transfusion** — Room temperature; gently agitate; infuse over 30-60 min via filter.
- **Cryoprecipitate** — Concentrated fibrinogen, factor VIII, vWF; for fibrinogen

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