# 個案被開立sucralfate 1 g PO QID與ciprofloxacin 500 mg PO BID。護理師應執行哪一種給藥時間表？

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=391805&lang=zh-tw  
> language: zh-TW  
> subject: Medical Emergencies  
> category: PA

## 題目

個案被開立sucralfate 1 g PO QID與ciprofloxacin 500 mg PO BID。護理師應執行哪一種給藥時間表？

## 選項

1. 兩種藥都與餐同時給予
2. 只有症狀出現時才給sucralfate
3. Sucralfate空腹、飯前1小時與睡前給予；ciprofloxacin至少與sucralfate間隔2小時以避免結合 **✔ 正確答案**
4. 將sucralfate磨碎並與ciprofloxacin糖漿混合

**正確答案: 3**

## 解析

正確 (2)：Sucralfate應在空腹、飯前1小時與睡前服用，以在潰瘍上形成保護層。它會結合許多藥物，如fluoroquinolone、levothyroxine、phenytoin、digoxin、warfarin，因此需間隔≥2小時。(1) 結合會降低效果。(3) 不需要磨碎。(4) 是定時用藥，不是PRN。

## 深入解析

記憶提示 Sucralfate =「覆蓋潰瘍、與其他藥隔2小時」。因含鋁也可能造成便秘。

## 臨床情境

情境 50歲男性，十二指腸潰瘍使用sucralfate 1 g PO QID，並因蜂窩性組織炎使用ciprofloxacin 500 mg PO BID。正在進行用藥核對。

## 重要概念

- **硫糖鋁** — 鋁蔗糖八硫酸鹽；在潰瘍上形成凝膠保護層，並會結合多種藥物。
- **空腹給藥** — 飯前1小時與睡前服用，以最大化潰瘍表面覆蓋。
- **藥物結合間隔** — 與交互作用藥物至少間隔2小時，如fluoroquinolone、levothyroxine。

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