# 一名嚴重過敏性氣喘個案在診所接受omalizumab皮下注射。哪一項給藥後措施最符合FDA黑框警告？

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=391797&lang=zh-tw  
> language: zh-TW  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## 題目

一名嚴重過敏性氣喘個案在診所接受omalizumab皮下注射。哪一項給藥後措施最符合FDA黑框警告？

## 選項

1. 立即讓病人離開以縮短診所停留時間
2. 為節省資源在診所外給藥
3. 先給diphenhydramine再讓病人回家
4. 前幾次給藥後在診所觀察至少2小時，之後至少30分鐘，且立即可用過敏性休克急救用品；並衛教可能延遲至24小時的反應 **✔ 正確答案**

**正確答案: 4**

## 解析

正確 (2)：Omalizumab有FDA過敏性休克黑框警告，可能危及生命，可發生於第一次或任何後續劑量，有時延遲至24小時才發生。需在醫療場所觀察（初期2小時，穩定後續劑量30分鐘），並備妥過敏性休克急救用品。也會提供病人腎上腺素自動注射器。(1,3) 不安全。(4) 預先用藥不能消除過敏性休克風險。

## 深入解析

記憶提示 Omalizumab（抗IgE）=「抗IgE要記得過敏性休克警告」。所有氣喘生物製劑（omalizumab、mepolizumab、benralizumab、dupilumab）都有過敏反應警告。

## 臨床情境

情境 28歲女性，嚴重過敏性氣喘，每4週接受omalizumab 300 mg SC。於診所給藥。

## 重要概念

- **奧馬珠單抗** — 用於嚴重過敏性氣喘與慢性蕁麻疹的抗IgE單株抗體。
- **過敏性休克監測** — 因生物製劑有過敏性休克風險，需給藥後觀察並立即備妥epinephrine。
- **氣喘生物製劑** — 重度氣喘追加治療，如omalizumab、mepolizumab、benralizumab、reslizumab、dupilumab。

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