# 護理師教導一名囊性纖維化9歲兒童的家長使用dornase alfa霧化治療。哪一句話表示正確理解此藥角色？

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=391793&lang=zh-tw  
> language: zh-TW  
> subject: Medical Emergencies  
> category: PA

## 題目

護理師教導一名囊性纖維化9歲兒童的家長使用dornase alfa霧化治療。哪一句話表示正確理解此藥角色？

## 選項

1. 這個藥可以治癒囊性纖維化。
2. 只有孩子咳嗽時才吸入這個藥。
3. Dornase alfa會切斷痰中的DNA，使濃稠黏液變稀；我們每天使用，之後做胸部物理治療來清除分泌物。 **✔ 正確答案**
4. 可以把dornase alfa和其他吸入藥混在同一個霧化器。

**正確答案: 3**

## 解析

正確 (2)：Dornase alfa（重組人類DNase）會切斷CF黏液中由嗜中性球釋放的細胞外DNA，使痰液變稀並改善清除。每日使用，接著做氣道清除，如胸部物理治療或震動背心。(1) 治療症狀，不是治癒。(3) 是每日控制藥，不是需要時才用。(4) 不可與其他吸入藥混在同一霧化器。

## 深入解析

記憶提示 Dornase alfa = “DNA-ase”，切斷黏液中的DNA。霧化器中要單獨使用，並搭配胸部物理治療促進清除。

## 臨床情境

情境 9歲兒童有囊性纖維化，開始dornase alfa 2.5 mg每日一次霧化。正在進行家長衛教。

## 重要概念

- **重組DNase藥物** — 重組人類DNase；切斷CF痰液中的DNA，降低黏稠度。
- **囊性纖維化** — CFTR突變造成的體染色體隱性疾病；肺與腸胃道黏液濃稠，需要每日氣道清除。
- **氣道清除** — 胸部物理治療、姿位引流、高頻胸壁震盪背心可幫助移動分泌物。

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