# A nurse assesses a 16-hour-old term newborn and notes visible jaundice on the face and chest. The mother is type O Rh-positive and the newborn's blood type is not yet known. Which is the nurse's best interpretation and action?

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> language: en  
> subject: Ante/Intra/Postpartum and Newborn Care  
> category: HPM

## Question

A nurse assesses a 16-hour-old term newborn and notes visible jaundice on the face and chest. The mother is type O Rh-positive and the newborn's blood type is not yet known. Which is the nurse's best interpretation and action?

## Option

1. Jaundice within the first 24 hours of life is pathologic — notify the provider, expect a total and direct bilirubin, blood type with direct Coombs test, and CBC, and prepare for possible phototherapy. **✔ Correct answer**
2. Jaundice in the first 24 hours is physiologic in term newborns; reassure the mother and recheck in 24 hours.
3. Jaundice this early is from breastfeeding-associated jaundice; encourage more frequent feedings only.
4. Jaundice within 24 hours is normal as long as the bilirubin doubles every 24 hours.

**Correct answer: 1**

## Explanation

Jaundice that appears within the first 24 hours of life is always pathologic in a term newborn and most often reflects hemolytic disease of the newborn — ABO incompatibility (O mother with non-O newborn), Rh incompatibility, G6PD deficiency, or sepsis. The nurse's priority is provider notification and the expected workup: total and direct bilirubin, blood type with direct Coombs (DAT), CBC with differential and reticulocyte count, and preparation for phototherapy if the bilirubin level meets nomogram thresholds. Choices 2, 3, and 4 are wrong: physiologic jaundice begins after 24 hours and peaks at days 3–5; breastfeeding-associated jaundice presents in the first week but is not a first-24-hour pattern; bilirubin doubling every 24 hours is not a normal finding.

## In-depth explanation

Pathologic jaundice appears in the first 24 hours, with total bilirubin rising more than 5 mg/dL per day or 0.2 mg/dL per hour, lasting more than 2 weeks in term infants or 3 weeks in preterm, or with direct bilirubin greater than 2 mg/dL. Physiologic jaundice appears after 24 hours, peaks at days 3 to 5 in term and 5 to 7 in preterm, and resolves by 1 to 2 weeks. Hemolytic causes include ABO incompatibility (O mother with non-O newborn — most common), Rh incompatibility (Rh-negative mother sensitized in a prior pregnancy), G6PD deficiency, and hereditary spherocytosis; the direct Coombs test (DAT) is positive in immune-mediated hemolysis. Workup includes total and direct bilirubin, blood type with DAT, and CBC with reticulocytes. Phototherapy thresholds are read off the Bhutani nomogram or AAP guideline charts plotting total bilirubin against postnatal age in hours and risk factors (gestational age, hemolysis, sepsis); exchange transfusion is reserved for very high levels or phototherapy failure.

## Clinical scenario

A nurse assesses a **16-hour-old term newborn** and notes **visible jaundice on the face and chest**. The mother is **type O Rh-positive** and the newborn's **blood type is not yet known**.

## Key concepts

- **Pathologic vs Physiologic Jaundice** — Pathologic: appears in the first 24 hours, total bilirubin rises >5 mg/dL/day or >0.2 mg/dL/hr, lasts >2 weeks (term) or >3 weeks (preterm), or direct bilirubin >2 mg/dL. Physiologic: appears after 24 hours, peaks day 3–5 in term, day 5–7 in preterm, resolves by 1–2 weeks.
- **Hemolytic Causes** — ABO incompatibility (O mother, non-O newborn — most common), Rh incompatibility (Rh-negative mother sensitized in prior pregnancy), G6PD deficiency, hereditary spherocytosis. Direct Coombs (DAT) is positive in immune-mediated hemolysis. Workup: total/direct bilirubin, type with DAT, CBC with reticulocytes.
- **Phototherapy Thresholds** — Bhutani nomogram or AAP guideline charts plot total bilirubin against postnatal age in hours and risk factors (gestational age, hemolysis, sepsis). Phototherapy is initiated when bilirubin crosses the threshold. Exchange transfusion is reserved for very high levels or when phototherapy is failing.

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