Correct sequence for pMDI with spacer
The correct order is
1, 3, 4, 2: shake and attach the inhaler to the spacer, breathe out fully away from the spacer, press the canister once and inhale slowly and deeply, then hold the breath for up to
10 seconds.
The spacer exists to solve the biggest pMDI problem: poor hand–breath coordination. When a patient presses the canister and inhales at slightly different times, much of the aerosol strikes the back of the throat instead of reaching the small airways. A spacer holds the medication cloud in a chamber, so the patient can inhale it over several seconds at their own pace. This is why the device must be prepared first and why the breath-hold at the end matters.
Shaking the inhaler before each use mixes the active drug with the propellant. If this step is skipped, the first actuation may deliver mostly propellant and little medication. Attaching the inhaler to the spacer immediately after shaking prevents the suspension from settling again before the dose is released.
Breathing out fully, away from the spacer is the next step. The patient should exhale to functional residual capacity before placing the mouthpiece in the mouth. Exhaling into the spacer would blow the medication out of the chamber and waste the dose. A slow, deep inhalation after pressing the canister draws the aerosol from the spacer into the lower airways rather than depositing it in the oropharynx.
The final breath-hold of up to 10 seconds allows particles to settle by gravity in the smaller conducting airways. Without this pause, much of the inhaled dose is immediately exhaled. For patients with COPD who may not tolerate a full 10-second hold, even a 4–5 second pause is better than none, but the teaching standard remains up to 10 seconds when possible.
Watch out! A common error is pressing the canister and then inhaling too fast or too late. With a spacer, the patient should begin inhaling immediately after actuation, using a slow, deep breath over about 3–5 seconds. Rapid inhalation creates turbulent flow that deposits more drug in the upper airway.
Key point! The sequence is not interchangeable. Shaking before exhalation ensures the drug is suspended; exhaling before actuation prevents wasting the dose; inhaling slowly after actuation moves the aerosol into the lungs; and breath-holding maximizes deposition. Reversing steps 3 and 4—pressing the canister before breathing out—would leave the medication sitting in the spacer while the patient exhales, reducing the available dose.
The studies reinforce why each step is evaluated separately. In one pediatric study, technique was scored across
eight individual steps, and improvement after video instruction was significant immediately but faded at later visits, indicating that the sequence must be rechecked at every encounter
[1]. In adults with asthma and COPD, correct pMDI technique was predicted by repeated observation and instruction, not by age or disease duration alone
[4]. Counseling that specifically addressed device steps improved technique with both pMDI alone and pMDI with a spacer, supporting the need to teach the ordered sequence rather than assume patients will infer it
[2]. Visual instruction materials also improved correct usage among untrained users, but the benefit depended on the clarity of the step-by-step sequence shown
[3].
For a 68-year-old with COPD, the nurse should demonstrate the full sequence, then have the patient return the demonstration. Because spacer technique degrades over time without reinforcement, each BHS follow-up visit should include a quick check of the order: shake and attach, breathe out away from the spacer, press once and inhale slowly and deeply, then hold the breath for up to
10 seconds.
References (research sources)
- [1]
Pressurised metered dose inhaler-spacer technique in young children improves with video instruction.Research articleShaw N, Le Souëf P, Turkovic L, McCahon L, Kicic A, Sly PD (2016) · DOI: 10.1007/s00431-016-2738-2
- [2]
Effect of counseling on inhalation technique of metered-dose inhaler alone and with MDI PLUS or AeroChamber2go.Research articleSobh AHM, Mohamed BME, Ahmed Sayed O, Harb HS, Abdelrahim MEA, Mohsen M. (2026) · DOI: 10.1080/02770903.2026.2618104
- [3]
Effects of modifying visual inhaler spacer usage instructions on correct usage rate of untrained users.Research articleTopal E, Arga M, Özmen H, Doğru M, Alataş C, Muştu EB (2020) · DOI: 10.1002/alr.22440
- [4]
Predictors of correct technique in patients using pressurized metered dose inhalers.Research articleBartolo K, Balzan M, Schembri EL, Asciak R, Mercieca Balbi D, Pace Bardon M (2017) · DOI: 10.1186/s12890-017-0386-6