Before any other diagnostic testing, inspect the eye for these cardinal signs of an open-globe injury:
- Peaked or irregular pupil: The pupil points toward the wound site due to iris prolapse.
- Shallow anterior chamber: Compare depth to the unaffected eye; a flattened chamber suggests corneal perforation with aqueous leakage.
- Visible uveal tissue or vitreous: Darkly pigmented tissue (iris or ciliary body) or clear gel extruding from the wound.
- Positive Seidel test: If performed, fluorescein dye diluted by leaking aqueous humor appears as a dark stream within the green dye pool under cobalt blue light.
- Subconjunctival hemorrhage with chemosis: Extensive, boggy hemorrhage may mask an underlying scleral rupture.