The earliest and most reliable indicator of acute compartment syndrome is pain out of proportion to the injury, unrelieved by analgesics. This is often accompanied by the 5 P's: Pain, Pallor, Paresthesia, Poikilothermia, and Paralysis (a late sign).
Immediate intervention is provider notification. Definitive treatment is urgent fasciotomy to decompress the compartment. Tissue ischemia can become irreversible within 6 to 8 hours, leading to necrosis, limb loss, or rhabdomyolysis.
Do not elevate the limb above heart level as this reduces arterial perfusion. Do not apply ice, which causes vasoconstriction. Do not give additional analgesics that mask ischemic pain and delay diagnosis.
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