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학습 자료 둘러보기 →In a 2-week-old newborn, prolonged jaundice lasting beyond 14 days is a critical finding. It often indicates unconjugated hyperbilirubinemia due to impaired hepatic conjugation.
The primary pathophysiological link is decreased activity of the glucuronyl transferase enzyme, which is dependent on thyroid hormone. This deficiency directly impairs bilirubin metabolism.
Do not dismiss jaundice persisting past 2 weeks as benign. While newborn screening programs exist, clinical vigilance for this subtle sign is essential to prevent irreversible neurodevelopmental delay.
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