Clinical context Fifteen minutes after an evolocumab injection, a 63-year-old develops generalized hives, lip and tongue swelling, hoarseness, and increasing work of breathing while still in the clinic. A client develops lip swelling, generalized hives, and hoarseness shortly after evolocumab. Which actions are appropriate? Select exactly 4 responses.
Select All That Apply
Choose your responses, then check the answer.
Explanation
Lip swelling, hives, and hoarseness indicate serious hypersensitivity with airway risk. Evolocumab should be discontinued, treated according to standard care, and avoided after a serious hypersensitivity reaction.
Quick answer Respond to evolocumab-associated angioedema as an airway emergency.
Why this is correct Observation alone or rechallenge can allow rapid progression. Documentation and medication reconciliation prevent inadvertent re-exposure.
Easy analogy or mental picture Use a closed medication-safety loop: identify the immune or cytotoxic exposure, connect the new findings, interrupt further harm, stabilize the client, and verify the response over time.
Memory hook Exposure, immune effect, organ toxicity, infection risk, immediate action, and serial reassessment.
NCLEX decision rule Choose the action that reduces the most immediate medication-related risk while preserving diagnostic evaluation and authorized treatment.
Why the other choices are wrong Options that continue the exposure, treat only one symptom, or delay reassessment leave the toxic or infectious process active.
References
1DailyMed: REPATHA (evolocumab)Subcutaneous administration, serious hypersensitivity including angioedema, discontinuation, and follow-up
Clinical contextFifteen minutes after an evolocumab injection, a 63-year-old develops generalized hives, lip and tongue swelling, hoarseness, and increasing work of breathing while still in the clinic.