An infant receiving diazoxide for congenital hyperinsulinism… | MyMerci
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Adverse Effects/Contraindications/Interactions

An infant receiving diazoxide for congenital hyperinsulinism develops new findings. Review the trend and select the best interpretation and plan.

Trend

Choose your responses, then check the answer.

TimeData
Before diazoxideWeight 4.8 kg; oxygen saturation 98% on room air; no edema
Day 4Weight 5.1 kg; mild periorbital edema; respirations 44/min
CurrentWeight 5.5 kg; generalized edema; respirations 66/min; oxygen saturation 89%; echocardiogram shows elevated right-sided pressure

Q1. How should the trend be interpreted?

Q2. Which next plan is appropriate?

Explanation
Rapid weight gain, edema, tachypnea, falling oxygen saturation, and elevated right-sided pressures suggest clinically significant fluid retention and diazoxide-associated pulmonary hypertension.
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