An older adult with diabetes and chronic renal failure is st… | MyMerci
Adverse Effects/Contraindications/Interactions PPT
Question

An older adult with diabetes and chronic renal failure is starting an isoniazid-containing tuberculosis regimen. Which prescription should the nurse expect to reduce a predictable neurologic adverse effect?

Explanation
Older age, diabetes, and chronic renal failure increase susceptibility to isoniazid-associated peripheral neuropathy; pyridoxine is recommended for clients with neuropathy risk factors.
Next question on this topicA nurse is reviewing the morning lab results for an adult client receiving warfarin for at…

In-depth explanation

Quick answer
Expect pyridoxine with isoniazid for this high-risk client.

Why this is correct
Isoniazid can cause dose-related peripheral neuropathy. CDC materials identify diabetes, renal failure, advanced age, HIV, pregnancy, alcoholism, and malnutrition among risk states where vitamin B6 support is used.

Easy analogy or mental picture
Add the vitamin guardrail before the tingling pathway becomes damaged.

Memory hook
INH plus neuropathy risk: think B6.

NCLEX decision rule
Assess baseline sensation, hepatic symptoms, adherence, interactions, and the full tuberculosis regimen rather than teaching one adverse effect in isolation.

Why the other choices are wrong
Vitamin K, calcium, and folate do not prevent the characteristic isoniazid neuropathy mechanism described here.
References
1CDC: Treatment of Latent TB Infection and TB Disease ModuleIsoniazid neuropathy risk and pyridoxine for clients with risk factors

Clinical scenario

Isoniazid teaching
Review neuropathy risks, pyridoxine, hepatic warning symptoms, alcohol avoidance, adherence, drug interactions, and tuberculosis follow-up.
Browse all questions No login required

Master the NCLEX-RN with MyMerci

Thousands of NCLEX-style questions with detailed rationale — in your language. Track your progress and study smarter.

Start for free
App Store Google Play
Read in another language: English한국어日本語繁體中文Tiếng Việt

For study reference only. Always follow current clinical guidelines and your institution’s protocols.