A client who ingested a large amount of extended-release bup… | MyMerci
Adverse Effects/Contraindications/Interactions PPT
Question

A client who ingested a large amount of extended-release bupropion is awake but agitated and tachycardic. Which action should the nurse take first?

Explanation
Extended-release bupropion overdose can produce delayed seizures, conduction abnormalities, dysrhythmias, and cardiovascular collapse; there is no specific antidote.
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In-depth explanation

Quick answer
Prepare for delayed seizures and dysrhythmias.

Why this is correct
The label reports seizures in about one third of overdose cases plus conduction disturbances, arrhythmias, cardiac failure, and arrest. Close monitored supportive care is required.

Easy analogy or mental picture
A quiet fuse can still lead to a delayed electrical storm.

Memory hook
Bupropion overdose: monitor brain and heart.

NCLEX decision rule
Do not use current wakefulness to exclude delayed extended-release toxicity.

Why the other choices are wrong
Discharge, redosing, and flumazenil do not address the known bupropion overdose pattern.
References
1DailyMed: Wellbutrin XLOverdose seizures, conduction disturbances, dysrhythmias, and supportive monitoring

Clinical scenario

Delayed-toxicity surveillance
Monitor neurologic status, ECG, hemodynamics, temperature, glucose, electrolytes, and seizure activity.
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For study reference only. Always follow current clinical guidelines and your institution’s protocols.