For each memantine finding, identify the appropriate interpretation.
Matrix
Choose your responses, then check the answer.
Explanation
Severe renal impairment limits the target immediate-release dose to 5 mg BID. A 10-mg BID order needs clarification, and several missed days may require restarting lower and retitrating.
Quick answer Match the plan to the 5-to-29 mL/min severe-renal band and the interruption history.
Why this is correct The memantine label recommends a target of 5 mg BID for severe renal impairment. It also states that several missed days may require resuming at a lower dose and retitrating; a single missed dose is not doubled.
Easy analogy or mental picture A narrowed kidney exit lowers the dose ceiling, and a long pause sends titration back toward the starting ramp.
Memory hook CrCl 5 to 29: target 5 mg BID; never double a missed dose.
NCLEX decision rule Interpret the current prescription only after checking formulation, clearance, last dose, and interruption duration.
Why the other choices are wrong Normal renal function does not require the severe-renal ceiling, and one missed dose is resumed on schedule rather than doubled.
References
1DailyMed: Memantine Hydrochloride TabletsTarget dose for severe renal impairment and caution in severe hepatic impairment
Memantine dose reconciliationVerify formulation, Cockcroft-Gault clearance, current dose, days missed, adverse effects, and the authorized retitration plan.