A client with sickle cell anemia takes hydroxyurea. Today th… | MyMerci
Adverse Effects/Contraindications/Interactions PPT
Question

A client with sickle cell anemia takes hydroxyurea. Today the absolute neutrophil count is 1,800/mm3. Which action should the nurse take?

Explanation
The Droxia label defines neutrophils below 2,000/mm3 as a toxic-range blood count and directs interruption until recovery, followed by dose reduction as indicated.
Next question on this topicA nurse is reviewing the morning lab results for an adult client receiving warfarin for at…

In-depth explanation

Quick answer
Hold hydroxyurea and notify the prescriber because the neutrophil count is in the labeled toxic range.

Why this is correct
Hydroxyurea can cause severe myelosuppression. The Droxia dosing table identifies neutrophils below 2,000/mm3 as toxic and recommends interruption with frequent reassessment until recovery.

Easy analogy or mental picture
The blood count is the safety gate for the next dose. When the neutrophil gate is below the labeled threshold, the medication waits.

Memory hook
Hydroxyurea plus ANC below 2,000/mm3: interrupt and reassess.

NCLEX decision rule
Review the current complete blood count before administration. When a labeled hold threshold is reached, prevent further exposure and notify the authorized prescriber for follow-up and dose management.

Why the other choices are wrong
Neutropenia is not a goal to ignore. Iron does not acutely correct medication-related neutropenia, and doubling a later dose would increase toxicity.
References
1DailyMed: DroxiaBlood-count thresholds and temporary interruption

Clinical scenario

Myelosuppression check
Trend neutrophils, platelets, hemoglobin, reticulocytes, symptoms of infection, last dose, and the current hydroxyurea plan.
Browse all questions No login required

Master the NCLEX-RN with MyMerci

Thousands of NCLEX-style questions with detailed rationale — in your language. Track your progress and study smarter.

Start for free
Read in another language: English한국어日本語繁體中文Tiếng Việt

For study reference only. Always follow current clinical guidelines and your institution’s protocols.