Quick answer Report hydrochlorothiazide before dofetilide is administered.
Why this is correct DailyMed lists concomitant hydrochlorothiazide use as contraindicated because it significantly increases dofetilide concentrations and QT-interval effects.
Easy analogy or mental picture Dofetilide is a narrow electrical lane. Hydrochlorothiazide pushes both drug exposure and QT risk into that lane, so the combination needs to be blocked before entry.
Memory hook Dofetilide plus hydrochlorothiazide is contraindicated.
NCLEX decision rule During medication reconciliation before a high-risk antiarrhythmic is started, identify labeled contraindications and notify the prescribing team before the first dose.
Why the other choices are wrong The other listed medications are not the labeled contraindicated combination being tested. Their presence does not replace the need for a full interaction and laboratory review.
References
1DailyMed: DofetilideHydrochlorothiazide contraindication and QT prolongation
Pre-dose reviewReconcile prescription, over-the-counter, and recently discontinued medications before the monitored dofetilide initiation protocol begins.