A client with exocrine pancreatic insufficiency takes pancrelipase with meals and snacks. Which finding best indicates that the medication is effective?
1Fasting blood glucose decreases, and thirst becomes less frequent
2Greasy stools decrease, and the client's weight begins to stabilize✓ Correct answer
3Serum lipase increases, and abdominal tenderness becomes more pronounced
4Urine output increases, and dependent edema becomes less noticeable
Explanation
Pancrelipase replaces digestive enzymes so fat, protein, and carbohydrate can be absorbed more effectively. Fewer greasy stools and stabilizing weight show improved digestion and nutrient absorption when dosing accompanies food.
Quick answer Less steatorrhea with stabilizing weight shows effective pancreatic enzyme replacement.
Why this is correct Without sufficient pancreatic enzymes, dietary fat remains poorly digested and produces bulky, oily stools and weight loss. Pancrelipase taken with food improves nutrient breakdown, so stool quality and nutritional status are practical response measures.
Easy analogy or mental picture Pancrelipase supplies missing tools to a digestive workshop so food can be taken apart for absorption. The analogy explains replacement but does not mean the medication restores pancreatic tissue or treats every cause of pain.
Memory hook Pancreatic enzymes working means less grease and steadier weight.
NCLEX decision rule Evaluate enzyme replacement by improved digestion and nutrition. Look for reduced steatorrhea, better weight trajectory, and fewer malabsorption symptoms rather than unrelated glucose, kidney, or edema changes.
Why the other choices are wrong Pancrelipase is not intended to lower glucose or increase urine output. Rising lipase and greater tenderness suggest ongoing pancreatic inflammation rather than therapeutic success.
References
[1]
NCSBN: 2026 NCLEX-RN Test PlanNational Council of State Boards of Nursing
[2]
DailyMed: Creon Pancrelipase Prescribing InformationU.S. National Library of Medicine, updated July 2026