Drag each finding to the acute glucose emergency it most strongly supports.
Matrix Multiple Choice
Choose your responses, then check the answer.
Explanation
DKA requires diabetes or glucose at least 200 mg/dL together with significant ketonemia and metabolic acidosis; euglycemic DKA may occur, especially with SGLT2 inhibitors. HHS requires marked hyperglycemia and hyperosmolality without severe ketonemia or acidosis, but mild ketonemia may be present. Hypoglycemia produces autonomic or neuroglycopenic findings that improve after glucose treatment.
Quick answer DKA = ketones plus acidosis; HHS = severe hyperglycemia plus hyperosmolality; hypoglycemia = low glucose with autonomic or neuroglycopenic findings.
Why this is correct The 2024 international consensus lowered the DKA glucose threshold and emphasizes direct beta-hydroxybutyrate measurement. DKA can occur with glucose below 200 mg/dL. HHS is defined by hyperglycemia and hyperosmolality with no severe ketonemia or acidosis; saying that HHS always has no ketones is too absolute because mild ketonemia can occur.
NCLEX decision rule Do not classify from glucose alone. Read glucose, ketones, pH or bicarbonate, osmolality, hydration, and mental status together, and recognize a possible mixed DKA-HHS presentation.
Reference
1ADA/EASD/JBDS/AACE/DTS hyperglycemic-crises consensus reportDiabetes Care, 2024
Emergency assessmentUse the current adult consensus criteria. DKA and HHS can overlap, and HHS can include mild ketonemia; classify each finding by its strongest pattern.
Beta-Hydroxybutyrate — The predominant circulating ketoacid in DKA and the preferred direct blood ketone measurement.
Hyperosmolality — Increased concentration of osmotically active particles in blood, a defining feature of HHS.
neuroglycopenia — Brain glucose deprivation causing confusion, seizure, coma in hypoglycemia.