Correct (2): Refeeding syndrome — when carbohydrates are introduced after starvation, insulin surge drives phosphate, magnesium, potassium intracellularly → severe deficiencies with arrhythmia, respiratory failure, seizures, heart failure. Prevention: start TPN at 25-50% of goal, advance slowly over 4-7 days, give thiamine 100 mg before/during initial feeding, replete phosphate/Mg/K before progressing. (1,3,4) Dangerous.
In-depth explanation
Memory Tip Refeeding = "Phosphate-Magnesium-Potassium DROP + Thiamine BEFORE carbs." Identify high risk: BMI 15%, no intake >10 days, low pre-feeding electrolytes.
Clinical scenario
Scenario 65-year-old female with severe protein-calorie malnutrition started on TPN. 48 hr later: dyspnea, confusion, weakness, phosphate 1.2, Mg 1.3, K 3.0.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.