Correct (2): TACO — circulatory overload from rapid/large-volume transfusion, especially in elderly/CHF/CKD. Signs: dyspnea, JVD, HTN, crackles, S3, rising BNP. Management: slow/stop transfusion, sit upright, O2, IV furosemide. Prevention: pre-transfusion diuretic, slower rate. TRALI differs — hypotension + non-cardiogenic pulmonary edema within 6 hours; treat with respiratory support. (1) TRALI has hypotension. (3) Anaphylaxis = hives + wheeze. (4) Septic = chills + fever shock.
In-depth explanation
Memory Tip TACO = "Too much volume — HYPERtension + JVD + responds to diuretic." TRALI = "Lung damage — HYPOtension + bilateral infiltrates + needs respiratory support." Both within 6 hours but TACO is hypervolemia, TRALI is non-cardiogenic edema.
Clinical scenario
Scenario 82-year-old female CHF receiving 2 units PRBC; 90 min into infusion: acute dyspnea, JVD, BP 178/96, crackles, BNP rising.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.