Shortly after induction with succinylcholine and sevoflurane… | MyMerci
Adverse Effects/Contraindications/Interactions PPT
Question

Shortly after induction with succinylcholine and sevoflurane, an OR client develops masseter rigidity, rapid rise in end-tidal CO2 to 70, tachycardia, and temperature spike to 40°C. Which is the priority action?

Explanation
Correct (2): Malignant hyperthermia — autosomal dominant ryanodine receptor disorder triggered by succinylcholine and volatile anesthetics. Hallmarks: masseter rigidity, rising EtCO2, hyperthermia, tachycardia, acidosis, rhabdomyolysis. Antidote: IV dantrolene 2.5 mg/kg immediately (repeat to max 10 mg/kg). Stop triggers, cool, treat hyperkalemia and acidosis. (1,3,4) Fatal.

In-depth explanation

Memory Tip MH triggers = "Sux + Volatile gas (sevo/iso/des)." Dantrolene antidote. Family history → use non-triggering anesthetic. MHAUS hotline.

Clinical scenario

Scenario 18-year-old undergoing elective surgery received succinylcholine + sevoflurane. New: masseter rigidity, EtCO2 70, HR 145, temp 40°C, mottled skin.

Key concepts

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