Correct (2): Tacrolimus is metabolized by CYP3A4; potent inhibitors (grapefruit juice, clarithromycin, azole antifungals, diltiazem) raise levels, causing tremor, AKI, hypertension, hyperglycemia, neurotoxicity. Avoid grapefruit; coordinate any new drug with the transplant team. Target trough varies (e.g., 5-15 ng/mL depending on time post-transplant). (1,3,4) Unrelated.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.