During IV vincristine infusion, a client reports burning at … | MyMerci
Adverse Effects/Contraindications/InteractionsPPT
Question
During IV vincristine infusion, a client reports burning at the IV site. The nurse notes swelling and absent blood return. Which is the priority action?
1Apply ice and continue infusion
2Remove the IV and reinsert in the same vein
3STOP the infusion immediately, leave the IV catheter in place, aspirate residual drug, notify the provider, follow extravasation protocol (warm compress and hyaluronidase for vincristine), elevate limb, and document✓ Correct answer
4Increase the rate to flush the line
Explanation
Correct (2): Vincristine is a vesicant — extravasation requires immediate STOP, leave catheter in to aspirate residual, antidote per drug. Vinca alkaloids: warm compress + hyaluronidase. Anthracyclines: cold compress + dexrazoxane or DMSO. NEVER give vincristine intrathecally (fatal). (1,3,4) Worsen.
In-depth explanation
Memory Tip Extravasation antidotes — "WARM-Vinca" (hyaluronidase) vs "COLD-Anthracycline" (dexrazoxane/DMSO). Vincristine IT = fatal — never label syringe IV/IT together.
Clinical scenario
Scenario Adult receiving vincristine IV via peripheral line; reports burning, swelling and absent blood return.
Key concepts
Vesicant chemotherapy — Drugs causing severe tissue necrosis on extravasation; vincristine, anthracyclines.