During IV vincristine infusion, a client reports burning at … | MyMerci
Adverse Effects/Contraindications/Interactions PPT
Question

During IV vincristine infusion, a client reports burning at the IV site. The nurse notes swelling and absent blood return. Which is the priority action?

Explanation
Correct (2): Vincristine is a vesicant — extravasation requires immediate STOP, leave catheter in to aspirate residual, antidote per drug. Vinca alkaloids: warm compress + hyaluronidase. Anthracyclines: cold compress + dexrazoxane or DMSO. NEVER give vincristine intrathecally (fatal). (1,3,4) Worsen.

In-depth explanation

Memory Tip Extravasation antidotes — "WARM-Vinca" (hyaluronidase) vs "COLD-Anthracycline" (dexrazoxane/DMSO). Vincristine IT = fatal — never label syringe IV/IT together.

Clinical scenario

Scenario Adult receiving vincristine IV via peripheral line; reports burning, swelling and absent blood return.

Key concepts

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