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Medication Administration PPT
Question

Which pretreatment results are most important for the nurse to verify?

Explanation
Infliximab suppresses tumor necrosis factor alpha and can reactivate latent tuberculosis or hepatitis B. The nurse should verify tuberculosis evaluation and hepatitis B testing before treatment and report positive or indeterminate findings for management. The other test pairs do not address the major infection-reactivation risks associated with infliximab.
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In-depth explanation

Clinical reasoning
TNF-alpha is important for containing granulomatous infection. Blocking it can allow latent tuberculosis to become active, and immunosuppression can permit hepatitis B reactivation.

Decision rule
Before a TNF-alpha inhibitor, verify infection screening, assess current infection, and review vaccine status; monitor for infection during and after therapy.

Clinical scenario

Scenario A 35-year-old client with refractory Crohn disease is scheduled to begin infliximab 5 mg/kg IV.

Key concepts

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For study reference only. Always follow current clinical guidelines and your institution’s protocols.