A client with ulcerative colitis starting mesalamine asks th… | MyMerci
Medical EmergenciesPA
Question
A client with ulcerative colitis starting mesalamine asks the nurse about expected adverse effects. Which response is most accurate?
1Expect significant weight gain
2No adverse effects with this drug
3Monitor for headache, nausea, flank pain (interstitial nephritis), and rare hypersensitivity; baseline and periodic BUN/Cr and LFT recommended✓ Correct answer
4Expect daily severe constipation
Explanation
Correct (2): Mesalamine (5-ASA) commonly causes headache, GI upset, and rash; serious effects include interstitial nephritis, pancreatitis, and rare hypersensitivity that may mimic UC flare. Baseline/periodic BUN/Cr/LFT monitoring. (1,3,4) Incorrect.
In-depth explanation
Memory Tip 5-ASA = "Mesa-LAMINE = LAMINate the colon" anti-inflammatory; renal vigilance critical. Sulfasalazine adds sulfa allergy + folate deficiency.
Clinical scenario
Scenario 32-year-old female with ulcerative colitis starting mesalamine 1.2 g PO TID. Outpatient teaching.
Key concepts
Mesalamine (5-ASA) — Topical anti-inflammatory for UC and mild Crohn; PO, enema, suppository.