A client with severe COPD is starting roflumilast 500 mcg PO… | MyMerci
Medical Emergencies PA
Question

A client with severe COPD is starting roflumilast 500 mcg PO daily. Which adverse effect should the nurse teach the client to monitor for and report?

Explanation
Correct (2): Roflumilast (PDE4 inhibitor) has notable adverse effects: weight loss (often >5% body weight), neuropsychiatric symptoms including depression and suicidal ideation, and GI symptoms (nausea, diarrhea, headache). Monitor weight, mood, and bowel pattern. Contraindicated in moderate-severe liver disease. (1,3,4) Not key roflumilast effects.

In-depth explanation

Memory Tip Roflumilast = "Roflu-MIND-and-WEIGHT" — psychiatric and weight effects. Used in severe COPD with chronic bronchitis and history of exacerbations as ADD-ON.

Clinical scenario

Scenario 64-year-old male with severe COPD and frequent exacerbations starting roflumilast 500 mcg PO daily. Outpatient teaching.

Key concepts

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For study reference only. Always follow current clinical guidelines and your institution’s protocols.