A client with severe COPD is starting roflumilast 500 mcg PO… | MyMerci
Medical EmergenciesPA
Question
A client with severe COPD is starting roflumilast 500 mcg PO daily. Which adverse effect should the nurse teach the client to monitor for and report?
1Hyperglycemia
2Weight loss, mood changes including new depression or suicidal ideation, GI symptoms (nausea, diarrhea, headache)✓ Correct answer
3Tinnitus
4Hypertension
Explanation
Correct (2): Roflumilast (PDE4 inhibitor) has notable adverse effects: weight loss (often >5% body weight), neuropsychiatric symptoms including depression and suicidal ideation, and GI symptoms (nausea, diarrhea, headache). Monitor weight, mood, and bowel pattern. Contraindicated in moderate-severe liver disease. (1,3,4) Not key roflumilast effects.
In-depth explanation
Memory Tip Roflumilast = "Roflu-MIND-and-WEIGHT" — psychiatric and weight effects. Used in severe COPD with chronic bronchitis and history of exacerbations as ADD-ON.
Clinical scenario
Scenario 64-year-old male with severe COPD and frequent exacerbations starting roflumilast 500 mcg PO daily. Outpatient teaching.
Key concepts
Roflumilast — Phosphodiesterase-4 (PDE4) inhibitor; reduces exacerbations in severe COPD with chronic bronchitis.