Correct (2): Loratadine is a second-generation antihistamine with minimal CNS penetration and minimal sedation — safe for drivers, pilots, and operators of heavy equipment. (1) Sedation is uncommon. (3) Alcohol unnecessary and can compound any mild sedation. (4) Loratadine is for daily allergy control, not PRN rash.
In-depth explanation
Memory Tip 2nd-gen antihistamine = "Non-sedating, no anticholinergic, once-daily" — loratadine, cetirizine, fexofenadine, desloratadine, levocetirizine. Cetirizine slightly more sedating than loratadine/fexofenadine.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.