Correct (2): Tiotropium HandiHaler capsules are inhaled only, never swallowed. Place the capsule in the device, pierce it, then inhale forcefully (forceful for DPI, unlike MDI). Once-daily controller dosing. Rinse mouth to reduce anticholinergic dry mouth. (1) Not BID/PRN. (3,4) Capsules are for inhalation, not oral.
In-depth explanation
Memory Tip Tiotropium = "Once-daily, Inhale-only, Anti-Spit (dry mouth)." DPI requires FORCEFUL inhalation; MDI requires SLOW deep inhalation. Caution Use spacer with MDI, not with DPI.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.