A client taking galantamine is brought to the emergency depa… | MyMerci
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Medication Administration PPT
Question

A client taking galantamine is brought to the emergency department with profuse salivation, vomiting, diarrhea, muscle weakness, a heart rate of 42/min, and shallow respirations. Which action should the nurse anticipate?

Explanation
Severe salivation, vomiting, diarrhea, bradycardia, muscle weakness, and respiratory depression during galantamine therapy indicate cholinergic toxicity. The nurse should hold galantamine, support the airway and ventilation, notify the emergency treatment team or poison center, and prepare a prescribed tertiary anticholinergic such as atropine. Additional galantamine can worsen the crisis, while naloxone does not reverse cholinergic excess and oral fluids are unsafe with respiratory compromise.
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In-depth explanation

Clinical reasoning
Galantamine inhibits acetylcholinesterase. Excess exposure can overstimulate muscarinic and nicotinic receptors, producing secretions, gastrointestinal hyperactivity, bradycardia, muscle weakness, and respiratory failure.

Decision rule
Treat suspected galantamine overdose as a cholinergic emergency: stop exposure, support ventilation, obtain poison-control guidance, and administer atropine according to the prescribed response-based plan.

Clinical scenario

Scenario 75-year-old male on galantamine 16 mg/day; daughter doubled the dose by mistake yesterday. Presents with drooling, HR 42, miosis, cramping, diarrhea, sweating.

Key concepts

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For study reference only. Always follow current clinical guidelines and your institution’s protocols.