Correct (2): Gabapentin is renally eliminated; in eGFR 15-29, dose should be reduced (e.g., 200-700 mg/day in divided doses). Failure to adjust causes accumulation with sedation, ataxia, falls, and respiratory depression — especially dangerous in older adults. (1) Standard dose risks toxicity. (3) Higher dose worsens harm. (4) Administration route does not change the underlying issue.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.