A 72-year-old client with chronic kidney disease (eGFR 28 mL… | MyMerci
Medical Emergencies PA
Question

A 72-year-old client with chronic kidney disease (eGFR 28 mL/min) is prescribed gabapentin 300 mg PO three times daily for postherpetic neuralgia. Which is the nurse's priority action?

Explanation
Correct (2): Gabapentin is renally eliminated; in eGFR 15-29, dose should be reduced (e.g., 200-700 mg/day in divided doses). Failure to adjust causes accumulation with sedation, ataxia, falls, and respiratory depression — especially dangerous in older adults. (1) Standard dose risks toxicity. (3) Higher dose worsens harm. (4) Administration route does not change the underlying issue.

In-depth explanation

Memory Tip Gabapentin/Pregabalin = "Renal Reduction Required." Check eGFR before initiation and at each dose change. Caution FDA boxed warning for respiratory depression when combined with opioids or other CNS depressants.

Clinical scenario

Scenario 72-year-old male, postherpetic neuralgia. CKD stage 4 (eGFR 28 mL/min). Provider orders gabapentin 300 mg PO TID.

Key concepts

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For study reference only. Always follow current clinical guidelines and your institution’s protocols.