SSRI/SNRI discontinuation syndrome arises when a serotonergic antidepressant is stopped abruptly or tapered too quickly after at least 4 to 6 weeks of use. Risk is highest with short-half-life agents (paroxetine, venlafaxine, duloxetine) and very high chronic doses; lowest with fluoxetine because of its long active metabolite. Onset 1 to 3 days after stopping; resolves spontaneously over 1 to 3 weeks. Mnemonic FINISH: Flu-like, Insomnia, Nausea, Imbalance/dizziness, Sensory disturbances ("brain zaps"), Hyperarousal/agitation. Distinguishing from depression relapse: discontinuation syndrome has somatic dominance, comes within days, resolves rapidly with restarting; depression relapse takes weeks and lacks the sensory/somatic features. Standard nursing response: (1) recognize and contact prescriber; (2) restart paroxetine at the previous dose with rapid symptom resolution, then taper gradually over weeks (often 5 mg every 1 to 2 weeks); alternative is to switch to fluoxetine for a few days to bridge, then taper because fluoxetine self-tapers; (3) reassure that this is not relapse and is reversible, but screen for true depression separately; (4) educate to never stop abruptly and to plan tapers; (5) symptomatic relief — rest, hydration, brief antiemetic if needed. Reassuring without action, indefinite cessation, and adding SSRI are wrong.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.