Reye syndrome is a rare but life-threatening encephalopathy with fatty liver degeneration that follows viral illness in children given salicylates (aspirin, bismuth subsalicylate). The typical sequence is influenza or varicella, fever, and aspirin use, then 3 to 5 days later sudden persistent vomiting, lethargy, irritability, confusion, seizures, and coma. Mortality is high and survivors may have neurologic sequelae. The CDC, FDA, AAP, and American Heart Association all recommend avoiding aspirin and aspirin-containing products in children and adolescents under 19 years with confirmed or suspected viral illness, particularly influenza and varicella. Safer choices for fever and pain in this age group are weight-based acetaminophen (10 to 15 mg/kg every 4 to 6 hours, max 75 mg/kg/day not to exceed adult ceiling) or ibuprofen for older infants (5 to 10 mg/kg every 6 to 8 hours, with food, only in children over 6 months and not in dehydrated children). Bismuth subsalicylate (Pepto-Bismol) should also be avoided because it converts to salicylate. Teaching: always read child OTC labels for hidden salicylates, watch for warning signs (persistent vomiting, lethargy, behavior change, seizures), seek emergency care for those signs.
For study reference only. Always follow current clinical guidelines and your institution’s protocols.