A client on long-term high-dose alprazolam admits to abruptl… | MyMerci
NCLEX-RN SIPC
Question

A client on long-term high-dose alprazolam admits to abruptly stopping it 36 hours ago. He has tremor, anxiety, BP 168/98, HR 116, and one witnessed generalized seizure. Which action is the priority?

Explanation
Abrupt cessation of high-dose long-term benzodiazepines can cause life-threatening withdrawal: seizures, autonomic instability, even delirium. Treatment is substitution with a long-acting BZD (diazepam, chlordiazepoxide) — or phenobarbital in some protocols — at a stabilizing dose followed by gradual taper over weeks to months. Discharge after one dose is unsafe. Haloperidol does NOT prevent BZD withdrawal seizures and may lower seizure threshold. Restraint without pharmacologic management is harmful.

In-depth explanation

Tapers typically reduce dose by 10-25 percent every 1-2 weeks. Faster tapers in inpatient with monitoring. Avoid abrupt discontinuation — can be fatal.

Clinical scenario

Long-term alprazolam 2 mg q6h for 4 years. Last dose 36 hours ago.

Key concepts

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For study reference only. Always follow current clinical guidelines and your institution’s protocols.