A client with metastatic breast cancer presents with confusi… | MyMerci
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Management of Care

A client with metastatic breast cancer presents with confusion, polyuria, dehydration, and corrected calcium 14.6 mg/dL. Which interventions should the nurse anticipate? Select all that apply.

Select All That Apply

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Explanation
Severe hypercalcemia of malignancy needs volume expansion FIRST with isotonic saline 200-300 mL/hr targeting urine output 100-150 mL/hr to enhance calciuresis. Calcitonin gives a rapid but tachyphylactic calcium drop within 12-48 hours bridging to bisphosphonate. Zoledronic acid provides sustained reduction over days but is renally cleared — denosumab is preferred if creatinine clearance under 30. Fluid restriction WORSENS hypercalcemia by reducing renal calcium clearance. Loop diuretics are NOT routinely used unless there is fluid overload from rehydration.
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