Quick answerClarify the
atorvastatin-clarithromycin interaction before giving either planned dose.
Why this is correctClarithromycin is a strong CYP3A4 inhibitor that raises atorvastatin exposure. The labeling advises that atorvastatin should not exceed 20 mg daily when clarithromycin is required, because myopathy and rhabdomyolysis risk increases.
Easy analogy or mental pictureThe antibiotic closes a major exit route for atorvastatin, so the statin can accumulate.
Memory hookClarithromycin blocks CYP3A4; check the statin plan.NCLEX decision ruleClarify a new prescription when a labeled interaction makes the current dose unsafe; do not independently discontinue or redesign the regimen.
Why the other choices are wrongTiming separation does not reverse enzyme inhibition, routine observation misses a preventable interaction, and an independent 10-day hold exceeds nursing authority.
References
1DailyMed: Atorvastatin calciumCYP3A4 interaction and clarithromycin dose limitation