A client taking atorvastatin 40 mg daily receives a new pres… | MyMerci
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Medication Administration PPT
Question

A client taking atorvastatin 40 mg daily receives a new prescription for clarithromycin. Which action should the nurse take before administering the medications?

Explanation
Clarithromycin inhibits CYP3A4 and can increase atorvastatin exposure and the risk of myopathy or rhabdomyolysis. Atorvastatin 40 mg exceeds the labeled 20 mg daily limit when clarithromycin must be used, so the nurse should clarify the regimen before administration.
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In-depth explanation

Quick answer
Clarify the atorvastatin-clarithromycin interaction before giving either planned dose.

Why this is correct
Clarithromycin is a strong CYP3A4 inhibitor that raises atorvastatin exposure. The labeling advises that atorvastatin should not exceed 20 mg daily when clarithromycin is required, because myopathy and rhabdomyolysis risk increases.

Easy analogy or mental picture
The antibiotic closes a major exit route for atorvastatin, so the statin can accumulate.

Memory hook
Clarithromycin blocks CYP3A4; check the statin plan.

NCLEX decision rule
Clarify a new prescription when a labeled interaction makes the current dose unsafe; do not independently discontinue or redesign the regimen.

Why the other choices are wrong
Timing separation does not reverse enzyme inhibition, routine observation misses a preventable interaction, and an independent 10-day hold exceeds nursing authority.
References
1DailyMed: Atorvastatin calciumCYP3A4 interaction and clarithromycin dose limitation
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For study reference only. Always follow current clinical guidelines and your institution’s protocols.