A nurse on a cardiac unit is reviewing reversal protocols for patients receiving anticoagulants. Which statements are accurate? Select all that apply.

Correct: 2, 3, 4, 6. (2) Protamine sulfate is administered IV to neutralize unfractionated heparin; the dose is based on the amount of heparin received recently because heparin is cleared over time. (3) Idarucizumab is a specific antibody fragment used for emergency reversal of dabigatran in life-threatening bleeding or urgent surgery. (4) Major warfarin-associated bleeding requires rapid factor replacement with 4-factor prothrombin complex concentrate plus IV vitamin K for sustained reversal; vitamin K alone acts too slowly for intracranial hemorrhage. (6) Protamine can be used for low-molecular-weight heparin exposure, but it only partially reverses the anticoagulant effect. Incorrect: (1) Oral vitamin K alone does not provide sufficiently rapid reversal for active intracranial hemorrhage. (5) Fresh frozen plasma requires more volume and acts more slowly than 4-factor PCC; it is generally reserved for situations in which PCC is unavailable or unsuitable. For major bleeding, stop the anticoagulant and follow the current institutional reversal protocol with urgent pharmacy, hematology, or stroke-team guidance.