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Sleep

Unit 5 · Topic 10Sleep
1.Overview & Pathophysiology

Sleep restores the body and brain, consolidates memory, supports immune function, and regulates mood and metabolism. Two processes control it: the circadian rhythm (a roughly 24-hour clock in the hypothalamus, set mainly by light and signaled by melatonin release in darkness) and sleep pressure that builds the longer a person is awake.

Sleep stages (current scoring combines the older stages 3 and 4 into a single N3 stage)

StageFeatures
N1Light transition sleep; easily awakened
N2Largest share of the night; heart rate and temperature fall
N3 (slow-wave, deep sleep)Hardest to awaken; growth hormone release, tissue repair; sleepwalking and night terrors arise here
REMRapid eye movements, vivid dreaming, muscle paralysis (atonia), variable heart rate and BP, brain activity similar to waking; important for memory and mood

A cycle of NREM and REM lasts about 90 minutes, repeating 4–6 times a night; N3 dominates early in the night and REM later. After REM deprivation (for example, after stopping sedatives or alcohol), REM rebound causes vivid dreams.

Sleep need: adults need 7 hours or more per night; children 6–12 years need 9–12 hours and teens 13–18 years need 8–10 hours.

Changes with aging: total sleep time is similar or slightly less, but N3 and REM decrease, night awakenings increase, sleep efficiency falls, and the circadian rhythm shifts earlier (advanced sleep phase — sleepy early in the evening and waking early in the morning). Nocturia, pain, medications, and napping add to the problem.

Common sleep disorders

DisorderKey features
InsomniaDifficulty falling asleep, staying asleep, or waking too early, with daytime impairment, at least 3 nights a week for 3 months (chronic)
Obstructive sleep apnea (OSA)Repeated upper airway collapse; loud snoring, witnessed pauses in breathing, gasping, excessive daytime sleepiness, morning headache; linked to obesity, hypertension, dysrhythmias, stroke
Restless legs syndromeUrge to move the legs with unpleasant sensations, worse at rest and in the evening, relieved by movement; associated with iron deficiency, kidney disease, pregnancy
REM sleep behavior disorderLoss of REM atonia → acting out dreams (talking, kicking, punching); injury risk; can precede Parkinson's disease
NarcolepsySudden sleep attacks, cataplexy, sleep paralysis, hallucinations at sleep onset
Circadian rhythm disordersShift work, jet lag, advanced or delayed sleep phase
ParasomniasSleepwalking, night terrors (N3), enuresis
2.Assessment Findings
  • Sleep history first — the simplest, noninvasive starting point: usual bedtime and wake time, time to fall asleep, awakenings, naps, perceived quality, daytime function, bedtime routines, environment, caffeine, alcohol, nicotine, screen use, medications, pain, nocturia, mood, stress, work schedule
  • Sleep diary for 1–2 weeks
  • Bed partner report — snoring, pauses in breathing, leg kicking, dream enactment
  • Children: bedtime routine, fears or resistance, and snoring or breathing pauses (often enlarged tonsils and adenoids), reported by caregivers
  • Physical signs of sleep loss: dark circles, yawning, irritability, poor concentration, slowed reactions
  • OSA risk: neck circumference, obesity, hypertension, crowded airway; screening with STOP-Bang
3.Diagnostics
ToolPurpose
Pittsburgh Sleep Quality Index (PSQI)Self-report of sleep quality over the past month (19 items grouped into 7 component scores)
Insomnia Severity IndexSeverity of insomnia symptoms
Epworth Sleepiness ScaleDaytime sleepiness — likelihood of dozing in 8 everyday situations
STOP-BangScreening for OSA risk
ActigraphyWrist device that records movement to estimate sleep-wake patterns over days to weeks in the client's normal environment
PolysomnographyOvernight laboratory study recording brain waves (EEG), eye movements (EOG), muscle activity (EMG), heart rhythm, airflow, respiratory effort, SpO₂, and leg movements — the gold standard for OSA and many sleep disorders
Home sleep apnea testSimplified airflow and oximetry study for suspected uncomplicated OSA

Preparing for polysomnography: avoid caffeine and alcohol the afternoon and evening before (and naps that day); wash hair and avoid hair products so electrodes stick; bring usual nightwear and take usual medications unless told otherwise.

4.Medical Management
  • Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment for chronic insomnia — stimulus control, sleep restriction, cognitive therapy, relaxation, and sleep hygiene.
  • OSA: weight loss, positional therapy, continuous positive airway pressure (CPAP), oral appliances, and in some cases surgery or hypoglossal nerve stimulation.
  • Restless legs: check iron studies and replace iron if ferritin is low; avoid triggers (caffeine, alcohol, sedating antihistamines, some antidepressants); medications if needed.
  • REM sleep behavior disorder: make the bedroom safe; medications per provider.

Drug safety for sleep medications

Drug classSafety points
Benzodiazepines (e.g., lorazepam, temazepam)Sedation, confusion, falls, dependence, withdrawal; respiratory depression with opioids or alcohol; avoid in older adults and in OSA; not for long-term use; FDA boxed warning (2020) for abuse, dependence, and withdrawal — taper, do not stop abruptly
"Z-drugs" (zolpidem, eszopiclone, zaleplon)Next-morning impairment (lower doses for women); avoid in older adults (Beers Criteria); complex sleep behaviors such as sleepwalking or sleep-driving (boxed warning) — stop if they occur; falls; take only when able to stay in bed 7–8 hours
Orexin receptor antagonists (suvorexant, lemborexant)Next-day drowsiness; contraindicated in narcolepsy
Sedating antidepressants (trazodone, low-dose doxepin)Orthostatic hypotension, priapism (trazodone)
Sedating antihistamines (diphenhydramine)Anticholinergic — confusion, urinary retention, constipation, falls; avoid in older adults
MelatoninUseful mainly for circadian problems; supplement content varies

All hypnotics add to the central nervous system depression of alcohol and opioids — combining them can cause dangerous sedation and respiratory depression.

5.Nursing Interventions
  1. Safety first with hypnotics: assess sedation and respiratory status, use fall precautions, keep the bed low and the call light within reach, and help with nighttime toileting.
  2. Create a sleep-promoting environment in hospital: dim lights at night and bright light during the day to support the circadian rhythm; reduce noise (alarm management, quiet conversations, closing doors) — noise cannot be eliminated entirely, but unnecessary noise can; offer earplugs and eye masks; comfortable room temperature.
  3. Cluster care to allow blocks of uninterrupted sleep (ideally 90 minutes or more); schedule medications and vital signs to avoid waking the client when safe.
  4. Relieve symptoms that disturb sleep: give analgesics before bedtime for clients with chronic pain; manage dyspnea, nausea, and nocturia (fluids earlier in the day, diuretics in the morning); toilet before sleep.
  5. Support bedtime routines: personal hygiene, reading, relaxation, prayer, back rub, warm drink without caffeine.
  6. CPAP use in hospital: clients with OSA should use their own CPAP at night and during naps, especially when receiving opioids; monitor SpO₂.
  7. Nonpharmacologic first: relaxation, positioning, and environment before requesting a hypnotic.
  8. Document sleep patterns and the client's own report of rest.
6.Client Education

Sleep hygiene and behavioral strategies

  • Keep the same wake time every day, including weekends.
  • Go to bed only when sleepy; if unable to sleep after about 20 minutes, get up and do something quiet in dim light, then return (stimulus control).
  • Use the bed only for sleep and sex; keep the bedroom dark, quiet, and cool.
  • Avoid caffeine in the afternoon and evening, alcohol near bedtime (it fragments sleep), nicotine, and heavy meals late at night.
  • Regular exercise, but not within a few hours of bedtime.
  • Limit screens before bed; avoid long or late naps.
  • A warm bath about 1–2 hours before bed can help sleep onset.

Hypnotic safety: never combine with alcohol or opioids; do not drive the next morning if drowsy; rise slowly to prevent falls; do not stop long-term benzodiazepines abruptly.

Shift workers: caffeine early in the shift rather than toward the end; bright light during the night shift; dark, quiet bedroom (blackout curtains) and a consistent sleep block after work; plan rest before driving home.

OSA: use CPAP every night; clean the mask and tubing; weight loss; avoid alcohol and sedatives; sleep on the side.

7.Complications & Red Flags
ConcernWhy it matters
Untreated OSAHypertension, atrial fibrillation, stroke, motor vehicle crashes; opioid-induced respiratory depression after surgery
Hypnotic use in older adultsFalls, hip fracture, delirium
Complex sleep behaviors on Z-drugsInjury, sleep-driving — stop the drug
Sleep deprivation in hospitalDelirium, impaired healing, pain sensitivity
Dream enactmentInjury to client or bed partner
Excessive daytime sleepinessDrowsy driving — advise not to drive until treated
8.High-Yield Points
  • N3 (deep) sleep = growth hormone and tissue repair; REM = dreaming and memory, muscle atonia
  • Sleep cycles last about 90 minutes; adults need at least 7 hours
  • Aging: less deep and REM sleep, more awakenings, early morning waking (advanced phase)
  • Sleep history and diary come first in assessment
  • Epworth = daytime sleepiness; PSQI = sleep quality; actigraphy = long-term patterns at home
  • Polysomnography records EEG, EOG, EMG, airflow, SpO₂ — gold standard; avoid caffeine and alcohol before
  • OSA: loud snoring, witnessed apneas, daytime sleepiness; CPAP
  • Restless legs: urge to move, relieved by movement; check iron
  • REM sleep behavior disorder: acting out dreams
  • CBT-I is first-line for chronic insomnia
  • Hypnotics + alcohol → additive CNS and respiratory depression; avoid benzodiazepines, Z-drugs, and diphenhydramine in older adults
  • Hospital: dim at night, bright by day, reduce noise, cluster care, analgesia at bedtime

Country Notes

United States

  • The American Academy of Sleep Medicine recommends CBT-I as first-line therapy for chronic insomnia; the FDA requires a boxed warning on zolpidem, eszopiclone, and zaleplon for complex sleep behaviors.
  • Drowsy driving is a recognized safety issue; commercial drivers with suspected OSA may need evaluation before certification.

Philippines

  • Night-shift work in business process outsourcing (call centers) is common; shift-work sleep problems and caffeine or energy-drink use are relevant assessment points.
  • Hospital wards may be shared and noisy with family watchers present; negotiate quiet hours and lighting with families to protect sleep.

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