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Obsessive-Compulsive and Related Disorders

Unit 4 · Topic 20Obsessive-Compulsive and Related Disorders
1.Overview & Pathophysiology

This DSM-5-TR chapter groups disorders characterized by repetitive thoughts or behaviors that the person feels driven to perform. They were separated from anxiety disorders in DSM-5, although anxiety is often prominent.

Core concepts

  • Obsessions: recurrent, intrusive, unwanted thoughts, urges, or images that cause marked anxiety or distress (e.g., contamination, harm, doubt, symmetry, taboo thoughts). The person tries to ignore, suppress, or neutralize them
  • Compulsions: repetitive behaviors (washing, checking, ordering) or mental acts (counting, praying, repeating words) performed to reduce the distress caused by obsessions or to prevent a feared event. They give short-term relief but maintain the disorder through negative reinforcement
  • Symptoms are time-consuming (more than 1 hour a day) or cause significant distress or impairment

Neurobiology — dysfunction of the cortico-striato-thalamo-cortical (frontal–striatal–thalamic) circuit, involving the orbitofrontal cortex, anterior cingulate, and caudate; serotonin dysregulation (the basis for SSRI response), with glutamate and dopamine contributions. Genetic factors are significant. Childhood-onset cases can follow streptococcal or other infections (PANS/PANDAS) in a subset.

Disorders in this chapter

DisorderKey features
Obsessive-compulsive disorder (OCD)Obsessions, compulsions, or both. Insight specifier: good or fair / poor / absent insight with delusional beliefs; tic-related specifier
Body dysmorphic disorder (BDD)Preoccupation with perceived defects in appearance that are not observable or appear slight to others; repetitive behaviors (mirror checking, grooming, skin picking, reassurance-seeking, comparing). Muscle dysmorphia specifier. High rates of suicidal ideation; cosmetic procedures rarely help and often worsen distress
Hoarding disorderPersistent difficulty discarding possessions regardless of value, due to a perceived need to save them and distress at discarding; clutter makes living areas unusable. Specifier: with excessive acquisition
Trichotillomania (hair-pulling disorder)Recurrent hair pulling causing hair loss, with repeated attempts to stop
Excoriation (skin-picking) disorderRecurrent skin picking causing lesions, with repeated attempts to stop
Substance/medication-induced; due to another medical condition; other specified (e.g., body-focused repetitive behavior such as nail biting or lip biting, obsessional jealousy)—

Tooth grinding (bruxism) is not a disorder in this chapter; sleep-related bruxism is classified with sleep-related movement conditions.

Distinguish from obsessive-compulsive personality disorder (OCPD) — a pervasive pattern of perfectionism, rigidity, and control that the person usually sees as appropriate (ego-syntonic), without true obsessions and compulsions. OCD symptoms are typically ego-dystonic (recognized as excessive).

2.Assessment Findings
  • Content, frequency, and triggers of obsessions; type of rituals; time spent daily; degree of distress and interference with work, school, relationships, and self-care (key measures of severity)
  • Insight level; avoidance patterns; family accommodation (relatives participating in rituals)
  • Physical consequences: chapped, cracked, bleeding, or infected hands from washing; skin lesions and infection from picking; alopecia, and trichobezoar (hair ball causing GI obstruction) if hair is swallowed; falls, fire hazards, pests, and poor sanitation in hoarding
  • Depression and suicide risk (especially BDD), tics, substance use, eating disorders
  • Older adults who hoard: self-neglect, fall and fire risk, possible cognitive impairment
3.Diagnostics
ToolUse
Yale-Brown Obsessive Compulsive Scale (Y-BOCS); children's version (CY-BOCS)Severity; tracks treatment response
Body Dysmorphic Disorder QuestionnaireBDD screening
Saving Inventory-Revised; Clutter Image RatingHoarding severity
Home safety assessmentHoarding (exits, fire, sanitation, structural safety)
Medical and neurologic exam; streptococcal testing if abrupt pediatric onsetSecondary causes
ECG before clomipramineConduction abnormalities
4.Medical Management

Psychotherapy — first-line

  • Exposure and response prevention (ERP): graded exposure to the feared trigger (e.g., touching a "contaminated" object) while resisting or delaying the compulsion; anxiety rises, then declines without the ritual, and the client learns the feared outcome does not occur
  • CBT with cognitive restructuring (inflated responsibility, overestimation of threat, need for certainty)
  • Habit reversal training for trichotillomania and excoriation disorder: awareness training, competing response (e.g., clenching fists, holding a stress ball), and social support; stimulus control (gloves, covering mirrors, keeping nails short)
  • CBT for hoarding: motivation enhancement, sorting and decision-making skills, gradual discarding practice, reduced acquiring — done collaboratively with the client
  • CBT for BDD: exposure, reducing mirror checking and camouflage, perceptual retraining

Medications

DrugKey points
SSRIs (first-line: fluoxetine, fluvoxamine, sertraline, paroxetine, escitalopram)Fluoxetine, fluvoxamine, sertraline, paroxetine, and clomipramine are FDA-approved for OCD; escitalopram is used off-label. OCD often needs higher doses than depression and a longer trial (8–12 weeks) before judging response. Adverse effects: GI upset, insomnia, sexual dysfunction, hyponatremia, bleeding risk; boxed warning for suicidality under 25; serotonin syndrome; taper to stop. Fluvoxamine strongly inhibits CYP1A2 — dangerous with tizanidine and raises clozapine and theophylline levels
Clomipramine (TCA)Effective for OCD; anticholinergic effects, sedation, orthostatic hypotension, weight gain, seizure risk (dose-related), cardiac conduction delay; lethal in overdose; never within 2 weeks of an MAOI
Antipsychotic augmentationLow-dose risperidone or aripiprazole for partial SSRI response; monitor metabolic effects and EPS
BenzodiazepinesNot effective for OCD symptoms

Procedures for severe refractory OCD: deep transcranial magnetic stimulation (FDA-cleared for OCD) and, in specialized centers, deep brain stimulation.

5.Nursing Interventions

Listed in priority order.

  1. Physical safety and basic needs
    • Treat skin damage from washing or picking (gentle cleansers, emollients, wound care, infection monitoring)
    • Ensure nutrition, hydration, sleep, and hygiene are not displaced by rituals
    • Assess suicide risk, particularly in BDD and with comorbid depression
  2. Do not abruptly block rituals — forcibly stopping a compulsion causes severe anxiety. Early in care, allow time for rituals within a structured daily schedule, then gradually limit them in agreement with the client and the treatment plan
  3. Support ERP as planned by the team — encourage graded exposure and delaying the ritual; praise effort; do not physically restrain the client from rituals or use punishment
  4. Therapeutic communication
    • Acknowledge the distress ("You seem very worried that someone could get in"), explore feelings, and help identify triggers
    • Avoid arguing about the logic of obsessions or giving repeated reassurance ("That's not true, don't worry") — reassurance acts like a compulsion and keeps the cycle going
    • Explore coping alternatives together
  5. BDD — validate the distress without confirming or debating the perceived flaw; explore thoughts and feelings; support CBT and discourage repeated cosmetic procedures
  6. Hoarding
    • Priority is safety (fire exits, falls, sanitation) — assess the home with the client and negotiate small, concrete changes first
    • Never discard items without consent or organize forced clean-outs; they damage trust and are followed by rapid re-accumulation
    • Coordinate with community services (adult protective services, housing, fire safety) when there is serious risk
  7. Hair pulling and skin picking — identify antecedent situations and emotions (boredom, stress, perfectionism), teach competing responses, keep hands busy, and provide wound care
6.Client Education
  • OCD is a medical condition linked to brain circuits — not a character flaw; effective treatment exists
  • ERP works by facing fears without performing rituals; anxiety drops with practice
  • SSRIs need 8–12 weeks at an adequate dose to reduce OCD symptoms and often need higher doses; do not stop suddenly; report worsening mood or suicidal thoughts
  • Clomipramine: rise slowly (dizziness), manage dry mouth and constipation, avoid alcohol, report palpitations or seizures, store safely
  • Family: reduce accommodation (joining rituals, giving constant reassurance) gradually and supportively; avoid criticism
  • Hoarding: set small, achievable goals (one area, one category at a time)
  • Skin and hair: keep nails short, use gloves or bandages as barriers, moisturize after necessary handwashing
7.Complications & Red Flags
ComplicationWhat to watch for
SuicideBDD, severe OCD with depression, hopelessness
Skin infection, cellulitisExcessive washing, picking
TrichobezoarAbdominal pain, vomiting, obstruction in hair eaters
Home hazardsFire, falls, infestations, blocked exits, eviction (hoarding)
Clomipramine toxicitySeizures, dysrhythmias, wide QRS
Serotonin syndromeAgitation, hyperthermia, clonus with combined serotonergic drugs
Social and occupational declineHours spent on rituals, avoidance
8.High-Yield Points
  • Compulsions reduce the anxiety caused by obsessions — relief reinforces the cycle
  • Severity = time consumed (more than 1 hour/day) and interference with daily functioning
  • ERP = graded exposure + resisting/delaying the ritual — the key psychotherapy
  • SSRIs first-line; higher doses and 8–12-week trials; clomipramine is an alternative (seizures, cardiac toxicity)
  • Circuit: frontal–striatal–thalamic dysfunction; serotonin
  • Do not abruptly stop rituals early in care; schedule and gradually limit
  • Avoid arguing and repeated reassurance; acknowledge feelings
  • BDD: perceived flaw not observable to others; high suicide risk; cosmetic surgery does not help
  • Hoarding: never discard without consent; safety first, small negotiated steps
  • Trichotillomania and excoriation → habit reversal training
  • OCD is ego-dystonic; OCPD is ego-syntonic perfectionism without true rituals

Country Notes

United States

  • Hoarding with self-neglect in older adults may be referred to adult protective services and local fire or code agencies; procedures vary by state and locality.
  • Deep TMS devices are FDA-cleared for OCD as an adjunct treatment.

Philippines

  • The Mental Health Act (Republic Act 11036, 2018) requires informed consent and the least restrictive intervention — community interventions for hoarding should be collaborative.
  • The NCMH Crisis Hotline (1553 from landlines) is available 24 hours for clients with suicidal thoughts; check the NCMH website for the mobile numbers.

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