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The nose warms, humidifies, and filters inspired air, and the paranasal sinuses drain into it through narrow openings. Anything that swells the mucosa or blocks drainage causes congestion, pressure, and infection risk. The anterior septum contains a rich vascular network (Kiesselbach plexus), the source of most nosebleeds.
| Disorder | Key mechanism | Hallmarks |
|---|---|---|
| Allergic rhinitis | IgE-mediated reaction to allergens (pollen, dust mites, dander, mold); seasonal or perennial | Sneezing, itchy nose and eyes, clear watery rhinorrhea, congestion; pale boggy turbinates, "allergic shiners" |
| Nonallergic (vasomotor) rhinitis | Nasal hyperreactivity without IgE sensitization | Rhinorrhea and congestion triggered by temperature change, strong odors, smoke, spicy food, alcohol; allergy tests negative |
| Rhinitis medicamentosa | Rebound congestion from overuse of topical decongestant sprays | Worsening congestion after more than a few days of spray use |
| Acute rhinosinusitis | Mostly viral; bacterial in a minority | Congestion, purulent discharge, facial pain or pressure, reduced smell |
| Chronic rhinosinusitis (CRS) | Persistent mucosal inflammation ≥ 12 weeks, with or without nasal polyps | Obstruction, discharge, facial pressure, loss of smell |
| Nasal polyps | Benign inflammatory outgrowths of sinus mucosa, usually bilateral | Obstruction, reduced smell, postnasal drip, snoring; painless, no external nasal deformity |
| Deviated septum | Congenital or traumatic displacement of the septum | One-sided obstruction, mouth breathing, snoring, recurrent sinusitis |
| Epistaxis | Rupture of vessels — about 90% anterior (Kiesselbach plexus); posterior bleeds are less common but heavier | Bleeding from the nares or down the throat |
| Nasal foreign body | Usually young children | One-sided foul-smelling discharge, obstruction |
Aspirin-exacerbated respiratory disease (Samter triad): nasal polyps + asthma + reactions to aspirin/NSAIDs.
Signs of acute bacterial rhinosinusitis (ABRS) — suspect when:
| Test | Use |
|---|---|
| Clinical diagnosis | Most rhinitis and acute sinusitis |
| Skin prick test / serum specific IgE | Positive in allergic rhinitis; negative in nonallergic rhinitis |
| Nasal endoscopy | Polyps, CRS confirmation, posterior bleeding source |
| CT of sinuses | CRS evaluation and surgical planning; not routine for uncomplicated acute sinusitis — reserved for suspected complications |
| CBC, coagulation studies (PT/INR, aPTT) | Recurrent or severe epistaxis, clients on anticoagulants, before nasal surgery |
| Beta-2 transferrin of nasal fluid | Confirms CSF leak |
Nonallergic rhinitis — avoid triggers; intranasal azelastine, INCS, or intranasal ipratropium for watery rhinorrhea.
Septoplasty / rhinoplasty — correct a deviated septum; internal splints or packing may be placed.
| Drug | Key safety points |
|---|---|
| Intranasal corticosteroids (fluticasone, mometasone, budesonide) | Nasal irritation, epistaxis, rarely septal perforation — aim away from the septum; minimal systemic absorption at usual doses |
| Topical decongestants (oxymetazoline) | Limit to 3 days — rebound congestion (rhinitis medicamentosa); caution in hypertension |
| Oral decongestants (pseudoephedrine) | ↑BP, ↑heart rate, insomnia, urinary retention; avoid with uncontrolled hypertension, heart disease, MAO inhibitors; caution in glaucoma and prostatic hyperplasia |
| Antihistamines | First-generation: sedation, anticholinergic effects, falls in older adults; second-generation: less sedation |
| Intranasal ipratropium | Nasal dryness; caution in narrow-angle glaucoma |
| Amoxicillin-clavulanate | Allergy history before the first dose; diarrhea, C. difficile risk, rash |
| Oral corticosteroids (short bursts) | Hyperglycemia, hypertension, mood changes, insomnia |
Listed in priority order.
| Complication | What to watch for |
|---|---|
| Orbital or intracranial spread of sinusitis | Periorbital swelling or redness, double vision, reduced vision, severe headache, stiff neck, confusion — urgent referral |
| Posterior epistaxis / hemorrhagic shock | Blood in the posterior pharynx, frequent swallowing, tachycardia, hypotension |
| Aspiration / airway obstruction | Coughing, choking with posterior bleeding or dislodged pack |
| CSF rhinorrhea (after trauma or sinus surgery) | Clear watery drainage, salty taste, worse with leaning forward — risk of meningitis |
| Septal hematoma | Painful bluish septal swelling after trauma — needs drainage to prevent septal necrosis |
| Toxic shock syndrome (nasal packing) | Fever, rash, hypotension |
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