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Antianxiety or Anxiolytic Medications | 마이메르시 MyMerci
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Antianxiety or Anxiolytic Medications

NCLEX Review Guide: Antianxiety/Anxiolytic Medications

Benzodiazepines

Common Benzodiazepines

  • Lorazepam (Ativan) - Short-acting, preferred in elderly due to no active metabolites
  • Alprazolam (Xanax) - Intermediate-acting, high potential for dependence
  • Diazepam (Valium) - Long-acting, used for alcohol withdrawal and muscle spasms
  • Clonazepam (Klonopin) - Long-acting, also used for seizure disorders

Memory Aid: "ABCD of Benzos"

Alprazolam - Anxiety (short-term)
Benzos cause sedation
Clonazepam - Convulsions too
Diazepam - Detox (alcohol withdrawal)

Key Points

  • Enhance GABA neurotransmitter activity, producing calming effects
  • High potential for tolerance, dependence, and withdrawal symptoms
  • Never discontinue abruptly - requires gradual tapering to prevent seizures

Non-Benzodiazepine Anxiolytics

Buspirone (BuSpar)

  • Mechanism: Partial serotonin receptor agonist, not related to benzodiazepines
  • Takes 2-4 weeks to achieve therapeutic effect, unlike immediate benzodiazepine action
  • No sedation, dependence potential, or withdrawal syndrome
  • Cannot be used for acute anxiety episodes due to delayed onset
Clinical Alert: Buspirone cannot substitute for benzodiazepines in withdrawal management

Nursing Considerations & Safety

Assessment & Monitoring

  1. Assess baseline anxiety level using standardized scales
  2. Monitor vital signs, especially respiratory rate and blood pressure
  3. Evaluate cognitive function and fall risk, particularly in elderly patients
  4. Screen for substance abuse history and concurrent alcohol use

Clinical Scenario

A 75-year-old patient with anxiety is prescribed lorazepam. Priority nursing actions include:

  • Start with lowest effective dose due to increased sensitivity
  • Implement fall precautions due to sedation and confusion risk
  • Monitor for paradoxical reactions (agitation, confusion)

Key Points

  • Never mix with alcohol - can cause fatal respiratory depression
  • Elderly patients require lower doses and closer monitoring
  • Assess for therapeutic effectiveness within 30-60 minutes of administration

Commonly Confused Concepts

Benzodiazepines Buspirone
Immediate onset (30-60 min) Delayed onset (2-4 weeks)
High dependence potential No dependence potential
Causes sedation No sedation
Used for acute anxiety Used for chronic anxiety
Requires tapering Can stop abruptly

Memory Aid: "BuSpar is the Bus that's Slow"

BuSpar (Buspirone) takes time to work like a slow bus, but it's safer for long-term travel (no dependence)!

Study Tips & Quick Checks

High-Yield NCLEX Points

  • Benzodiazepine antidote: Flumazenil (Romazicon)
  • Signs of benzodiazepine withdrawal: tremors, seizures, anxiety, insomnia
  • Contraindications: acute narrow-angle glaucoma, severe respiratory depression
  • Pregnancy category: Most are Category D (avoid in pregnancy)
Common Pitfalls:
  • Don't confuse buspirone's delayed onset with benzodiazepine immediate effects
  • Remember: flumazenil can precipitate withdrawal in dependent patients
  • Elderly patients may experience paradoxical excitement instead of sedation

Quick Check Questions

☐ Can you name the benzodiazepine antidote?
☐ Which anxiolytic takes 2-4 weeks to work?
☐ What's the biggest risk when stopping benzos abruptly?
☐ Which population needs lower doses of benzodiazepines?

Remember: You're preparing to keep patients safe! Master these concepts to provide excellent nursing care and pass your NCLEX with confidence. Every study session brings you closer to your RN license! 🌟

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