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A 5-year-old child presents with complaints of intense anal itching at night, irritability, and disturbed sleep patterns for the past two weeks. The child attends daycare and has recently started scratching their perianal area frequently. Upon questioning, the mother mentions seeing small white threads in the child's stool. Based on these symptoms, what parasitic infection would you suspect?
Answer: Pinworm infection (Enterobiasis) is the most likely diagnosis based on the characteristic nocturnal perianal itching and visualization of white, thread-like worms.
| Medication | Target Parasites | Dosing | Side Effects |
|---|---|---|---|
| Mebendazole | Pinworms, roundworms, hookworms | 100 mg once (pinworms); 100 mg BID for 3 days (others) | Abdominal pain, diarrhea |
| Albendazole | Pinworms, roundworms, hookworms | 400 mg once (>2 years); 200 mg once (1-2 years) | Headache, nausea, hepatotoxicity |
| Pyrantel pamoate | Pinworms, roundworms | 11 mg/kg (max 1g) once; repeat in 2 weeks for pinworms | GI disturbances, headache |
| Metronidazole | Giardia | 15 mg/kg/day divided TID for 5-7 days | Metallic taste, nausea, disulfiram-like reaction with alcohol |
| Nitazoxanide | Giardia, Cryptosporidium | 100 mg BID (1-3 years) or 200 mg BID (4-11 years) for 3 days | Abdominal pain, diarrhea, vomiting |
| Parameter | Pinworms | Roundworms | Hookworms | Giardia |
|---|---|---|---|---|
| Type | Helminth (nematode) | Helminth (nematode) | Helminth (nematode) | Protozoan |
| Primary Symptom | Perianal itching (nocturnal) | Abdominal pain, intestinal obstruction | Iron-deficiency anemia | Foul-smelling diarrhea, bloating |
| Transmission | Fecal-oral, autoinfection | Ingestion of eggs from contaminated soil | Skin penetration by larvae in soil | Ingestion of cysts in contaminated water |
| Diagnostic Test | Scotch tape test | Stool O&P, visualization of adult worms | Stool O&P, CBC (anemia) | Stool antigen test, O&P |
| Treatment | Mebendazole, pyrantel pamoate | Albendazole, mebendazole | Albendazole, mebendazole + iron | Metronidazole, nitazoxanide |
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